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The WHO Covid-19 Research Database is a resource created in response to the Public Health Emergency of International Concern (PHEIC). Its content remains searchable and spans the time period March 2020 to June 2023. Since June 2023, manual updates to the database have been discontinued.

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Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19.

Dudoignon, Emmanuel; Moreno, Nabila; Deniau, Benjamin; Coutrot, Maxime; Longer, Romain; Amiot, Quentin; Mebazaa, Alexandre; Pirracchio, Romain; Depret, François; Legrand, Matthieu.

Anaesth Crit Care Pain Med ; 39(4): 453-455, 2020 08.

Article in English | MEDLINE | ID: covidwho-603939

ABSTRACT

The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. SARS-CoV-2 has been suggested to modulate the renin-angiotensin-aldosterone system (RAAS). In this series of COVID-19 critically ill patients, we report evidence of activation of the RAAS in COVID-19 patients with AKI.

Subject(s)

Acute Kidney Injury/metabolism , Betacoronavirus , Coronavirus Infections/metabolism , Pneumonia, Viral/metabolism , Renin-Angiotensin System/physiology , Acute Kidney Injury/etiology , Acute Kidney Injury/therapy , Aged , Aldosterone/blood , COVID-19 , Coronavirus Infections/complications , Creatinine/blood , Critical Illness , Female , Humans , Intensive Care Units , Male , Middle Aged , Pandemics , Pneumonia, Viral/complications , SARS-CoV-2

ABSTRACT

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